CAFFEINE CONTRACTURES, TWITCH CHARACTERISTICS AND THE THRESHOLD FOR CA-2+-INDUCED CA-2+ RELEASE IN SKELETAL-MUSCLE FROM HORSES WITH CHRONIC INTERMITTENT RHABDOMYOLYSIS

被引:36
作者
BEECH, J
LINDBORG, S
FLETCHER, JE
LIZZO, F
TRIPOLITIS, L
BRAUND, K
机构
[1] HAHNEMANN UNIV,DEPT ANESTHESIOL,PHILADELPHIA,PA 19102
[2] AUBURN UNIV,COLL VET MED,SCOTT RITCHEY RES PROGRAM,NEUROMUSCULAR LABS,AUBURN,AL 36830
基金
美国农业部;
关键词
D O I
10.1016/0034-5288(93)90019-C
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Muscle from horses with intermittent exercise associated rhabdomyolysis was examined to determine if calcium regulation was abnormal. In vitro studies on semimembranosus muscle fibre bundles showed the time to 50 per cent relaxation of caffeine-induced contractures was shorter and the electrically elicited twitch longer in horses with exercise associated rhabdomyolysis. Substitution of strontium for calcium eliminated the difference in caffeine contracture between the normal and rhabdomyolysis horses. The threshold of calcium-induced calcium release was lower than normal in terminal cisternae-containing fractions of muscle from horses with rhabdomyolysis. Thoroughbreds with rhabdomyolysis had a shorter time to peak twitch tension than standardbreds, and normal thoroughbreds had a shorter caffeine contracture than normal standardbreds. There was no difference in fibre typing between breeds or groups. Either no histological changes or low grade to moderate degenerative myopathy was seen in muscle from horses with rhabdomyolysis. These results suggest horses with intermittent exercise associated rhabdomyolysis have abnormal calcium regulation.
引用
收藏
页码:110 / 117
页数:8
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