CEREBRAL METABOLITE DYNAMICS DURING TEMPORARY COMPLETE ISCHEMIA IN RATS MONITORED BY TIME-SHARED H-1 AND P-31 NMR-SPECTROSCOPY

被引：44

作者：

CHANG, LH

SHIRANE, R

WEINSTEIN, PR

JAMES, TL

机构：

[1] UNIV CALIF SAN FRANCISCO, SCH MED, DEPT NEUROL SURG, SAN FRANCISCO, CA 94143 USA

[2] UNIV CALIF SAN FRANCISCO, SCH MED, DEPT RADIOL, SAN FRANCISCO, CA 94143 USA

来源：

MAGNETIC RESONANCE IN MEDICINE | 1990年 / 13卷 / 01期

关键词：

D O I：

10.1002/mrm.1910130103

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The changes in cerebral phosphorus metabolites, intracellular pH, and lactate during 30 min of complete global ischemia and 2 h of reperfusion were monitored by time‐shared 1H and 31P in vivo NMR spectroscopy in rats. After the induction of ischemia, intracellular pH decreased from 7.14 ± 0.01 to 6.32 ± 0.10, and lactate concentration increased from 1.6 ± 0.4 to 15.8 ± 2.5 μmol/g; ATP and phosphocreatine were totally depleted, while inorganic phosphate increased 715 ± 47%. Within 1 h after blood flow was restored, high‐energy phosphates and lactate levels had recovered close to baseline levels. The changes in intracellular pH and lactate levels during ischemia and reperfusion correlated Well. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：6 / 13

页数：8

共 12 条

[1] SEQUENTIAL INVIVO MEASUREMENT OF CEREBRAL INTRACELLULAR METABOLITES WITH P-31 MAGNETIC-RESONANCE SPECTROSCOPY DURING GLOBAL CEREBRAL-ISCHEMIA AND REPERFUSION IN RATS
ANDREWS, BT
WEINSTEIN, PR
KENIRY, M
PEREIRA, B
[J]. NEUROSURGERY, 1987, 21 (05) : 699 - 708
[2] COMPARISON OF LACTATE CONCENTRATION DETERMINATIONS IN ISCHEMIC AND HYPOXIC RAT BRAINS BY INVIVO AND INVITRO H-1-NMR SPECTROSCOPY
CHANG, LH
PEREIRA, BM
WEINSTEIN, PR
KENIRY, MA
MURPHYBOESCH, J
LITT, L
JAMES, TL
[J]. MAGNETIC RESONANCE IN MEDICINE, 1987, 4 (06) : 575 - 581
[3] A BALANCED-MATCHED DOUBLE-TUNED PROBE FOR INVIVO H-1 AND P-31 NMR
CHANG, LH
CHEW, WM
WEINSTEIN, PR
JAMES, TL
[J]. JOURNAL OF MAGNETIC RESONANCE, 1987, 72 (01): : 168 - 172
[4] PHYSIOLOGICAL NMR-SPECTROSCOPY - FROM ISOLATED CELLS TO MAN - INTRODUCTION
COHEN, SM
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 508 : R10 - R10
[5] COMPARISON OF P-31-NMR SPECTRA OF INVIVO RAT BRAIN USING CONVOLUTION DIFFERENCE AND SATURATION WITH A SURFACE COIL - SOURCE OF THE BROAD COMPONENT IN THE BRAIN SPECTRUM
GONZALEZMENDEZ, R
LITT, L
KORETSKY, AP
VONCOLDITZ, J
WEINER, MW
JAMES, TL
[J]. JOURNAL OF MAGNETIC RESONANCE, 1984, 57 (03) : 526 - 533
[6] MOON RB, 1973, J BIOL CHEM, V248, P7276
[7] MEASUREMENT OF LACTATE ACCUMULATION BY INVIVO PROTON NMR-SPECTROSCOPY DURING GLOBAL CEREBRAL-ISCHEMIA IN RATS
RICHARDS, TL
KENIRY, MA
WEINSTEIN, PR
PEREIRA, BM
ANDREWS, BT
MURPHY, EJ
JAMES, TL
[J]. MAGNETIC RESONANCE IN MEDICINE, 1987, 5 (04) : 353 - 357
[8] A NEW DOUBLE-TUNED PROBE FOR CONCURRENT H-1 AND P-31 NMR
SCHNALL, MD
SUBRAMANIAN, VH
LEIGH, JS
CHANCE, B
[J]. JOURNAL OF MAGNETIC RESONANCE, 1985, 65 (01) : 122 - 129
[9] INTRACELLULAR PH DETERMINATION BY A P-31-NMR TECHNIQUE - THE 2ND DISSOCIATION-CONSTANT OF PHOSPHORIC-ACID IN A BIOLOGICAL SYSTEM
SEO, Y
MURAKAMI, M
WATARI, H
IMAI, Y
YOSHIZAKI, K
NISHIKAWA, H
MORIMOTO, T
[J]. JOURNAL OF BIOCHEMISTRY, 1983, 94 (03) : 729 - 734
[10] SIESJO BK, 1985, PROG BRAIN RES, V63, P121

← 1 2 →