MOTOR LEARNING IN PATIENTS WITH CEREBELLAR DYSFUNCTION

被引:172
作者
SANES, JN [1 ]
DIMITROV, B [1 ]
HALLETT, M [1 ]
机构
[1] NINCDS,MED NEUROL BRANCH,HUMAN MOTOR CONTROL SECT,BETHESDA,MD 20892
关键词
D O I
10.1093/brain/113.1.103
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
This study examined whether cerebellar dysfunction resulted in deficiencies of motor learning. Patients with cerebellar atrophy only or cerebellar atrophy combined with atrophy of the brainstem and age-matched normal subjects performed two tasks to assess improvements in skilled performance. The first task was repetitive tracing with the hand of an irregular geometric pattern with normal visual guidance, and the second task was repetitive tracing of a different geometric pattern with mirror-reversed vision. Patients with pathology limited to the cerebellum showed impairments in the skilled performance of the movement performed with normal vision that may have been related to a failure to alter movement strategy. Patients with added pathology in the brainstem exhibited impairments in adapting to mirror-reversed vision. Subsidiary experiments indicated that improvements of movements guided by mirror-reversed vision were mediated by vision. These results indicate that the cerebellum and its associated input pathways are involved in motor skill learning. © 1990 Oxford University Press.
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页码:103 / 120
页数:18
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共 44 条
[2]  
ALBUS J S, 1971, Mathematical Biosciences, V10, P25, DOI 10.1016/0025-5564(71)90051-4
[3]  
[Anonymous], 1967, CEREBELLUM NEURONAL, DOI 10.1007/978-3-662-13147-3
[4]   ANALYSIS OF CEREBELLAR MOTOR DISORDERS BY VISUALLY GUIDED ELBOW TRACKING MOVEMENT [J].
BEPPU, H ;
SUDA, M ;
TANAKA, R .
BRAIN, 1984, 107 (SEP) :787-809
[5]   ANALYSIS OF CEREBELLAR MOTOR DISORDERS BY VISUALLY-GUIDED ELBOW TRACKING MOVEMENT .2. CONTRIBUTION OF THE VISUAL CUES ON SLOW RAMP PURSUIT [J].
BEPPU, H ;
NAGAOKA, M ;
TANAKA, R .
BRAIN, 1987, 110 :1-18
[6]  
BLOEDEL JR, 1987, SCIENCE, V238, P1728
[7]  
Brindley, 1964, INT BRAIN RES ORG B, V3, P80
[8]   ACTIVITY OF DENTATE NEURONS DURING ARM MOVEMENTS TRIGGERED BY VISUAL, AUDITORY, AND SOMATESTHETIC STIMULI IN THE MONKEY [J].
CHAPMAN, CE ;
SPIDALIERI, G ;
LAMARRE, Y .
JOURNAL OF NEUROPHYSIOLOGY, 1986, 55 (02) :203-226
[9]   THE INFORMATION CAPACITY OF THE HUMAN MOTOR SYSTEM IN CONTROLLING THE AMPLITUDE OF MOVEMENT [J].
FITTS, PM .
JOURNAL OF EXPERIMENTAL PSYCHOLOGY, 1954, 47 (06) :381-391
[10]   THE COORDINATION OF ARM MOVEMENTS - AN EXPERIMENTALLY CONFIRMED MATHEMATICAL-MODEL [J].
FLASH, T ;
HOGAN, N .
JOURNAL OF NEUROSCIENCE, 1985, 5 (07) :1688-1703