CYTOGENETIC FINDINGS IN ACUTE MEGAKARYOBLASTIC LEUKEMIA (ANLL-M7)

被引：19

作者：

JOHANSSON, B ^{[1
]}

MERTENS, F ^{[1
]}

HEIM, S ^{[1
]}

KRISTOFFERSSON, U ^{[1
]}

MANDAHL, N ^{[1
]}

NILSSON, PG ^{[1
]}

MITELMAN, F ^{[1
]}

机构：

[1] UNIV LUND HOSP,DEPT MED,DIV HEMATOL,S-22185 LUND,SWEDEN

来源：

CANCER GENETICS AND CYTOGENETICS | 1990年 / 48卷 / 01期

关键词：

D O I：

10.1016/0165-4608(90)90224-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The clinical, morphologic, and cytogenetic findings in a patient with acute megakaryoblastic leukemia (ANLL-M7) are described. At the time of diagnosis, the karyotype contained three related clones: 47,XY,t(3;6)(p13;q27),+8,t(12;22)(p13;q12),+15,-21,-22, +der(22)t(21;22)(q11;p13)/47,XY,+8,del(9)(q22),t(12;22),+15,-21,-22,+der(22)/46,XY,+8, t(12;22),-21,-22,+der(22). Complete remission was achieved with intensive combination chemotherapy. At relapse 20 months later, there was clear evidence of clonal evolution, and the karyotype was now 45,XY,t(2;18)(q33;p11),del(9)(q22),t(12;22)(p13;q12),-16, +der(16)t(8;16)(q13;p13),-21,-22,+der(22)t(21;22)(q11;p13)/46,XY,t(2;18),del(9),t(12;22), -16,+der(16),-21,-22,+der(22),+mar. A comparison with the few previously cytogenetically analyzed cases of ANLL-M7 reveals that structural rearrangements of chromosomes 21 and 22 might be of primary importance in the pathogenesis of acute megakaryoblastic leukemia. © 1990.

引用

页码：119 / 123

页数：5

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