GENOMIC DNA 5' TO THE MOUSE AND HUMAN ANGIOTENSIN-CONVERTING ENZYME GENES CONTAINS 2 DISTINCT REGIONS OF CONSERVED SEQUENCE

被引：34

作者：

SHAI, SY ^{[1
]}

LANGFORD, KG ^{[1
]}

MARTIN, BM ^{[1
]}

BERNSTEIN, KE ^{[1
]}

机构：

[1] NIMH,CLIN NEUROSCI BRANCH,MOLEC NEUROGENET SECT,BETHESDA,MD 20892

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 167卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)90640-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genomic DNA 5′ to the mouse and human genes encoding angiotensin-converting enzyme has been isolated and analyzed. A sequence comparison identifies two discrete regions of genomic DNA that are highly conserved. One region, found immediately 5′ to the mouse and human ACE genes, is a GC rich segment that contains a "TATA box" and several potential Spl binding sites. The second conserved region is found further 5′ and contains several potential regulatory cis elements including a possible glucocorticoid responsive element. These two regions of genomic DNA may influence the rate of mRNA transcription from the angiotensin-converting enzyme gene. © 1990.

引用

页码：1128 / 1133

页数：6

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