FLUOROACETATE AND FLUOROCITRATE - MECHANISM OF ACTION

被引：134

作者：

CLARKE, DD

机构：

[1] Department of Chemistry, Fordham University, Bronx, 10458, NY

来源：

NEUROCHEMICAL RESEARCH | 1991年 / 16卷 / 09期

关键词：

FLUOROACETATE; FLUOROCITRATE; FLUOROACONITATE;

D O I：

10.1007/BF00965850

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The concept of lethal synthesis as suggested by Peters is reviewed in the light of the more recent work in this area. It is suggested that fluorocitrate is a "suicide" substrate for aconitase rather than a competitive inhibitor as originally suggested. The use of these substances to study glialneuronal relationships is considered.

引用

页码：1055 / 1058

页数：4

共 25 条

[1]

AOKI C, 1987, J NEUROSCI, V7, P2214

[2] TRIETHYL ALPHA-FLUOROACONITATE [J].