DIFFERENTIAL-EFFECTS OF CERULEIN AND BOMBESIN ON THE ETHANOL INTAKE IN THE RAT

被引:3
作者
GEWISS, M [1 ]
HEIDBREDER, C [1 ]
DEWITTE, P [1 ]
机构
[1] CATHOLIC UNIV LOUVAIN,PSYCHOBIOL LAB,1 PL CROIX SUD,B-1348 LOUVAIN,BELGIUM
来源
ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE | 1991年 / 99卷 / 02期
关键词
D O I
10.3109/13813459109146955
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Male Wistar rats were allowed to drink either water or water mixed with ethyl alcohol (4%, 8% and 12%) as part of a water-deprived procedure. The decapeptide caerulein (1,3 and 6-mu-g/kg i.p.), a cholecystokinin analog, decreased the intake of ethanol while the consumption of tap water remained unchanged in a choice paradigm. The addition of quinine (a bitter substance) in drinking bottles did not significantly modify the fluid consumption while the i.p. injection of caerulein produced a significant decrease in the consumption of the saccharin containing bottle. The i.p. administration of bombesin (10 and 20-mu-g/kg) failed to modify the intake of water or ethanol solution in water-deprived animals. Interpretations are given in terms of the action of the cholecystokinin analog on differences in the taste intensity induced by the beverage or in terms of a direct consequence of the caerulein-induced decreased gastric emptying effect leading to an accumulation of ethanol in the gut.
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页码:151 / 153
页数:3
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