ANTIZYME, A PROTEIN-INDUCED BY POLYAMINES, ACCELERATES THE DEGRADATION OF ORNITHINE DECARBOXYLASE IN CHINESE-HAMSTER OVARY-CELL EXTRACTS

被引：70

作者：

MURAKAMI, Y ^{[1
]}

TANAKA, K ^{[1
]}

MATSUFUJI, S ^{[1
]}

MIYAZAKI, Y ^{[1
]}

HAYASHI, S ^{[1
]}

机构：

[1] UNIV TOKUSHIMA, INST ENZYME RES, TOKUSHIMA 770, JAPAN

来源：

BIOCHEMICAL JOURNAL | 1992年 / 283卷

关键词：

D O I：

10.1042/bj2830661

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ornithine decarboxylase (ODC), the key regulatory enzyme for polyamine biosynthesis, is known to have a short intracellular half-life, and antizyme, an ODC-binding protein induced by polyamines, has been suggested to be involved in the process of ODC degradation. In the present study we demonstrated that antizyme markedly accelerated ATP-dependent degradation of ODC in vitro in an extract from ODC-overproducing Chinese-hamster ovary cells.

引用

页码：661 / 664

页数：4

共 31 条

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