NI-DTPA DOPED AGAROSE-GEL - A PHANTOM MATERIAL FOR GD-DTPA ENHANCEMENT MEASUREMENTS

被引：47

作者：

TOFTS, PS ^{[1
]}

SHUTER, B ^{[1
]}

POPE, JM ^{[1
]}

机构：

[1] UNIV NEW S WALES,SCH PHYS,KENSINGTON,NSW 2033,AUSTRALIA

来源：

MAGNETIC RESONANCE IMAGING | 1993年 / 11卷 / 01期

关键词：

PHANTOM MATERIAL; AGAROSE; GEL; RELAXATION TIMES; GD-DTPA; NI-DTPA;

D O I：

10.1016/0730-725X(93)90420-I

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In order to study the relationship between the concentration of Gd-DTPA in tissue, and the resulting changes in relaxation times and signal intensity, a phantom material that has similar relaxation times to tissue and that can be doped with Gd-DTPA is required. The 'tissue-equivalent'' material should not contain Gd; nor should it alter the relaxivities of Gd-DTPA from their values in aqueous solution (R1 = 4.5 sec-1 mM-1; R2 = 5.5 sec-1 mM-1 at 1.5 T). Conventional materials, based on CuSO4-, MnCl2-, or GdCl3/LaCl3-agarose mixtures, are not suitable, since Gd is displaced from the Gd-DTPA chelate. The new material, consisting of Ni-DTPA dissolved in agarose, is easy to prepare and does not interact with Cd-DTPA. Its relaxation times are stable; relaxivity R1 was within 4% of its aqueous value over 109 days. T1s have low dependence on temperature (0.2-1.0%/degrees-C at 21-degrees-C) and on field strength, allowing the material to be used as a relaxation time standard for quality assurance. Equations giving the concentration of Ni-DTPA and agarose to produce a required T1 and T2 are provided.

引用

页码：125 / 133

页数：9

共 19 条

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[6] Schneiders, Solutions of two paramagnetic ions for use in nuclear magnetic resonance phantoms, Med. Phys., 15, pp. 12-16, (1988)
[7] Howe, Relaxation times in paramagnetically doped agarose gels as a function of temperature and ion concentration, Magn. Reson. Imaging, 6, pp. 263-270, (1988)
[8] Kraft, Fatouros, Clarke, Kishore, An MRI phantom material for quantitative relaxometry, Magn. Reson. Med., 5, pp. 555-562, (1987)
[9] Tofts, Shuter, Pope, Society for Magnetic Resonance in Medicine Eleventh Annual Meeting, Ni-DTPA doped agarose—a tissue equivalent material for Gd-DTPA enhancement measurements, 1, (1992)
[10] Pope, Repin, A simple approach to T<sub>2</sub> imaging in MRI, Magn. Reson. Imaging, 6, pp. 641-646, (1988)

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