BUTYRATE AS A DIFFERENTIATING AGENT - PHARMACOKINETICS, ANALOGS AND CURRENT STATUS

被引：130

作者：

NEWMARK, HL

LUPTON, JR

YOUNG, CW

机构：

[1] MEM HOSP,MEM SLOAN KETTERING CANC CTR,DIGEST TRACT CARCINOGENESIS LAB,NEW YORK,NY 10021

[2] MEM HOSP,MEM SLOAN KETTERING CANC CTR,SLOAN KETTERING INST,IRVING WEINSTEIN LAB,NEW YORK,NY 10021

[3] MEM HOSP,MEM SLOAN KETTERING CANC CTR,DEV CHEMOTHERAPY SERV,GASTROENTEROL SERV,NEW YORK,NY 10021

[4] TEXAS A&M UNIV,GRAD FAC NUTR,COLLEGE STN,TX 77843

来源：

CANCER LETTERS | 1994年 / 78卷 / 1-3期

关键词：

BUTYRATE; BUTYRAMIDE; BUTYRATE ESTERS; TRIBUTYRIN;

D O I：

10.1016/0304-3835(94)90023-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The field of butyrate-induced differentiation of neoplastic and non-neoplastic cells is reviewed and possible clinical correlations considered with regard to butyrate, butyrate prodrugs and butyrate analogues. These topics are discussed from the point of view of the concentrations required in vitro for biologic effect, and likely pharmacokinetic behavior in vivo.

引用

页码：1 / 5

页数：5

共 29 条

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AUGERON C, 1984, CANCER RES, V44, P3961

[2]

BREITMAN TR, 1990, CANCER RES, V50, P6268

[3] TERMINAL DIFFERENTIATION OF HUMAN PROMYELOCYTIC LEUKEMIA-CELLS INDUCED BY DIMETHYL-SULFOXIDE AND OTHER POLAR COMPOUNDS [J].