THE MECHANISM OF THE REARRANGEMENT OF THE NEUROTOXIN BETA-ODAP TO ALPHA-ODAP

被引：22

作者：

DEBRUYN, A

BECU, C

LAMBEIN, F

KEBEDE, N

ABEGAZ, B

NUNN, PB

机构：

[1] STATE UNIV GHENT,PHYSIOL CHEM LAB,B-9000 GHENT,BELGIUM

[2] UNIV ADDIS ABABA,DEPT CHEM,ADDIS ABABA,ETHIOPIA

[3] UNIV LONDON KINGS COLL,DIV BIOMED SCI,LONDON WC2R 2LS,ENGLAND

来源：

PHYTOCHEMISTRY | 1994年 / 36卷 / 01期

关键词：

LATHRYUS SATIVUS; LEGUMINOSAE; NEUROTOXIN; NMR; NEUROLATHYRISM; OXALYL-DIAMINO ACIDS;

D O I：

10.1016/S0031-9422(00)97018-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The diketopiperazine suggested to be the intermediate during the spontaneous isomerization of beta-ODAP and alpha-ODAP was synthesized. Its behaviour was studied at selected pH values and provided evidence that its natural occurrence is unlikely. 2-Hydroxy-imidazolidine-2,4-dicarboxylic acid (for the rearrangement beta-ODAP <---->alpha-ODAP) or 2-hydroxy-pyrimidine-2,4-dicarboxylic acid (for the rearrangement gamma-ODAB <---->alpha-ODAB) are suggested to be the unstable intermediates.

引用

页码：85 / 89

页数：5

共 10 条

[1] THERMAL-ISOMERIZATION OF N-OXALYL DERIVATIVES OF DIAMINO ACIDS [J].