MIRACIL-D - EFFECT ON VISCOSITY OF DNA

被引：17

作者：

CARCHMAN, RA

HIRSCHBE.E

WEINSTEI.IB

机构：

[1] Institute of Cancer Research, Departments of Biochemistry and Medicine, Columbia University College of Physicians and Surgeons, New York, NY

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1969年 / 179卷 / 01期

关键词：

D O I：

10.1016/0005-2787(69)90131-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Miracil D caused an increase in the intrinsic and relative viscosities of native calf thymus DNA. This effect was completely reversed by the addition of spermine (5·10-5 M, Mg2+ (5·10-3 M and Na+ (5·10-2 M. Experiments with a series of congeners indicated that alkylation of the proximal side-chain nitrogen of the drug and sulfoxidation of the ring system abolished activity. The effect of the congeners on relative viscosity correlated well with those on the heat denaturation profile of DNA. © 1969.

引用

页码：158 / &

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