MAMMARY-CANCER - SELECTIVE ACTION OF THE ESTROGEN-RECEPTOR COMPLEX

被引：37

作者：

IP, M

MILHOLLAND, RJ

ROSEN, F

KIM, U

机构：

[1] Department of Experimental Therapeutics, Roswell Park Memorial Institute, Buffalo

来源：

SCIENCE | 1979年 / 203卷 / 4378期

关键词：

D O I：

10.1126/science.760195

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Progesterone receptors in the autonomous rat mammary tumor MTW-9B are reduced 80 to 90 percent after ovariectomy, but are not reduced if ovariectomized animals are given estrogen. Tumor growth, however, is independent of estrogen status and insensitive to pharmacological doses of estradiol. This represents an unusual system characterized by a selective action ofan inducing agent on the genome.

引用

页码：361 / 363

页数：3

共 26 条

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[4] ESTROGEN-RECEPTOR ACTIVITY AND ENDOCRINE STATUS IN DMBA-INDUCED RAT MAMMARY-TUMORS
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[J]. EUROPEAN JOURNAL OF CANCER, 1977, 13 (03) : 223 - 228
[5] PREDICTING RESPONSE TO ENDOCRINE THERAPY IN HUMAN BREAST-CANCER - HYPOTHESIS
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[J]. SCIENCE, 1975, 189 (4204) : 726 - 727
[6] HORWITZ KB, 1978, J BIOL CHEM, V253, P2223
[7] HORWITZ KB, 1977, CANCER RES, V37, P1733
[8] IP M, UNPUBLISHED
[9] IP MM, 1978, CANCER RES, V38, P2879
[10] HORMONE DEPENDENCY IN BREAST-CANCER
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[J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1976, 7 (11-1) : 911 - 917

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