SMARThivPack: A complexity free and cost effective "three tests" combo kit model for improving HIV patients monitoring standards in resource poor settings

被引:4
作者
Yari, Aboubakar [1 ]
Passo, Frederic S. [1 ]
Hounyet, Jean-Pierre [2 ]
机构
[1] Biotech Trop Inc, Parakou, Benin
[2] Hop St Jean de Dieu, Boko, Benin
关键词
HIV monitoring guidelines; resource poor countries; cost and complexity; alternative technologies;
D O I
10.6026/97320630002097
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We propose a second method at an implementation level with cost and complexity reductions for monitoring HIV patients in resource-limited settings. The model is SMARThivPack, a "three tests" combo kit. Cost and complexity reductions of HIV patient monitoring technologies were described in a first model (at a technology development stage) proposed earlier. In developed countries, HIV patient clinical management programs comport three laboratory tests containing CD4 count, viral load measurement and pharmaco-resistance testing. In most developing countries only CD4 count is performed without the other two tests. Cost and complexity of required technologies are the major challenges to the developing world to meeting the "three tests" standard. SMARThivPack model achieves the "three tests" standard in the developing world by optimizing technology choice as to favour cross-use of equipments, thereby reducing equipment cost at the laboratory implementation level. Equipment cross use also reduces complexity by reducing training time, promoting specialization and substantiating experience in equipment use. The second level cost and complexity reductions model sets the grounds for a third level, global coordination cost and complexity reductions model.
引用
收藏
页码:97 / 100
页数:4
相关论文
共 7 条
[1]   Rapid and sensitive oligonucleotide ligation assay for detection of mutations in human immunodeficiency virus type 1 associated with high-level resistance to protease inhibitors [J].
Beek, IA ;
Mahalanabis, M ;
Pepper, G ;
Wright, A ;
Hamilton, S ;
Langston, E ;
Frenkel, LM .
JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (04) :1413-1419
[2]  
Constantine NT, 2005, INDIAN J MED RES, V121, P519
[3]   HIV-1 viral load assays for resource-limited settings [J].
Fiscus, Susan A. ;
Cheng, Ben ;
Crowe, Suzanne M. ;
Demeter, Lisa ;
Jennings, Cheryl ;
Miller, Veronica ;
Respess, Richard ;
Stevens, Wendy .
PLOS MEDICINE, 2006, 3 (10) :1743-1750
[4]   Mutagenically separated PCR assay for rapid detection of M41L and K70R zidovudine resistance mutations in CRFO1_AE (Subtype E) human immunodeficiency virus type [J].
Myint, L ;
Ariyoshi, K ;
Yan, H ;
Frater, AJ ;
Auwanit, W ;
Pathipvanith, P ;
Yamada, K ;
Matsuda, M ;
Chiba, T ;
Fujita, K ;
McClure, M ;
Weber, JN ;
Sugiura, W .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (12) :3861-3868
[5]   Human immunodeficiency virus on the Web: A guided tour [J].
Shafer, RW ;
Deresinski, SC .
CLINICAL INFECTIOUS DISEASES, 2000, 31 (02) :568-577
[6]   Cheaper HIV drugs for poor nations bring a new challenge: Monitoring treatment [J].
Stephenson, J .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (02) :151-153
[7]   Novel enzyme-linked minisequence assay for genotypic analysis of human immunodeficiency virus type 1 drug resistance [J].
Sugiura, W ;
Shimada, K ;
Matsuda, M ;
Chiba, T ;
Myint, L ;
Okano, A ;
Yamada, K .
JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (11) :4971-4979