MOTOR-NEURON DISEASE IN A PATIENT WITH A MONOCLONAL IGMK DIRECTED AGAINST GM1, GD1B, AND HIGH-MOLECULAR-WEIGHT NEURAL-SPECIFIC GLYCOPROTEINS

被引：56

作者：

NOBILEORAZIO, E ^{[1
]}

LEGNAME, G ^{[1
]}

DAVERIO, R ^{[1
]}

CARPO, M ^{[1
]}

GIULIANI, A ^{[1
]}

SONNINO, S ^{[1
]}

SCARLATO, G ^{[1
]}

机构：

[1] UNIV MILAN,DEPT MED CHEM & BIOCHEM,I-20122 MILAN,ITALY

来源：

ANNALS OF NEUROLOGY | 1990年 / 28卷 / 02期

关键词：

D O I：

10.1002/ana.410280215

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In a patient with motor neuron disease and benign IgMk monoclonal gammopathy, the M rprotein reacted with the glycolipids GM1, GD1b, and asialo GM1 and, by immunoblot, with some high‐molecular‐weight neural‐specific glycoproteins. The main reactive bands had an approximate molecular weight of 250 and 400 kd, were most concentrated in the spinal cord, and were also bound by the lectin peanut agglutinin. The presence of the Gal(b̃1‐3) GalNAc epitope on these neural‐specific glycoproteins may help to explain the selective neurological impairment of the patient. Copyright © 1990 American Neurological Association

引用

页码：190 / 194

页数：5

共 20 条

[1] MORPHOMETRIC AND BIOCHEMICAL-STUDIES OF PERIPHERAL-NERVES IN AMYOTROPHIC LATERAL SCLEROSIS [J].

BRADLEY, WG ;

GOOD, P ;

RASOOL, CG ;

ADELMAN, LS .

ANNALS OF NEUROLOGY, 1983, 14 (03) :267-277

[2]

FREDDO L, 1986, NEUROLOGY, V36, P454, DOI 10.1212/WNL.36.4.454

[3]

GHIDONI R, 1980, J BIOL CHEM, V255, P6990

[4] GLYCOSPHINGOLIPIDS IN CELLULAR INTERACTION, DIFFERENTIATION, AND ONCOGENESIS [J].

HAKOMORI, SI .

ANNUAL REVIEW OF BIOCHEMISTRY, 1981, 50 :733-764

[5] CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].

LAEMMLI, UK .

NATURE, 1970, 227 (5259) :680-+

[6] MONOCLONAL IGM WITH UNIQUE SPECIFICITY TO GANGLIOSIDES GM1 AND GD1B AND TO LACTO-N-TETRAOSE ASSOCIATED WITH HUMAN MOTOR NEURON DISEASE [J].

LATOV, N ;

HAYS, AP ;

DONOFRIO, PD ;

LIAO, J ;

ITO, H ;

MCGINNIS, S ;

MANOUSSOS, K ;

FREDDO, L ;

SHY, ME ;

SHERMAN, WH ;

CHANG, HW ;

GREENBERG, HS ;

ALBERS, JW ;

ALESSI, AG ;

KEREN, D ;

YU, RK ;

ROWLAND, LP ;

KABAT, EA .

NEUROLOGY, 1988, 38 (05) :763-768

[7]

Lotan R, 1978, Methods Enzymol, V50, P361

[8] MOTOR NEURON SYNDROME AND MONOCLONAL IGM WITH ANTIBODY-ACTIVITY AGAINST GANGLIOSIDES GM1 AND GD1B [J].

NARDELLI, E ;

STECK, AJ ;

BARKAS, T ;

SCHLUEP, M ;

JERUSALEM, F .

ANNALS OF NEUROLOGY, 1988, 23 (05) :524-528

[9] ANTI-MYELIN-ASSOCIATED GLYCOPROTEIN IGM ANTIBODY-TITERS IN NEUROPATHY ASSOCIATED WITH MACROGLOBULINEMIA [J].

NOBILEORAZIO, E ;

FRANCOMANO, E ;

DAVERIO, R ;

BARBIERI, S ;

MARMIROLI, P ;

MANFREDINI, E ;

CARPO, M ;

MOGGIO, M ;

LEGNAME, G ;

BALDINI, L ;

SCARLATO, G .

ANNALS OF NEUROLOGY, 1989, 26 (04) :543-550

[10]

PATRIDGE SM, 1948, BIOCHEM J, V42, P238

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