THE EFFECT OF NEUROPEPTIDE-Y ON MUCOCILIARY ACTIVITY IN THE RABBIT MAXILLARY SINUS

The effect of neuropeptide Y (NPY) on mucociliary activity in the rabbit maxillary sinus was investigated in vivo by injecting NPY at increasing dosages into the maxillary artery, response being recorded photoelectrically. At dosages of 0.1-5.0-mu-g/kg, NPY reduced mucociliary activity dose-dependently, the maximum decrease being 14.6 +/- 1.8%, at a dosage of 5.0-mu-g/kg. The NPY-induced reduction of the mucociliary activity manifested brief latency, the peak effect occurring within 3 min followed by a slow return to the baseline value 4-9 min after injection. The response of mucociliary activity to NPY remained unaffected by pretreatment with the alpha-adrenergic antagonists yohimbine (alpha-2) at 100.0-mu-g/kg and phentolamine (alpha-1 + alpha-2) at 0.2-1.0 mg/kg, indicating that the effect of NPY is not mediated via alpha-receptors. Pretreatment with the calcium antagonist nifedipine at 100.0-mu-g/kg inhibited the effect of NPY, suggesting that the NPY-induced decrease may be calcium dependent.