SYNERGISTIC EFFECT OF GROWTH HORMONE-RELEASING HORMONE (GHRH) AND CLONIDINE IN STIMULATING GH RELEASE IN YOUNG AND OLD DOGS

被引：27

作者：

ARCE, V

CELLA, SG

LOCHE, S

GHIGO, E

DEVESA, J

MULLER, EE

机构：

[1] UNIV MILAN,DEPT PHARMACOL CHEMOTHERAPY & TOXICOL,I-20129 MILAN,ITALY

[2] FAC MED SANTIAGO,DEPT PHYSIOL,SANTIAGO,SPAIN

[3] UNIV TURIN,DEPT BIOMED,I-10124 TURIN,ITALY

来源：

BRAIN RESEARCH | 1990年 / 537卷 / 1-2期

关键词：

GROWTH HORMONE RELEASE; GROWTH HORMONE-RELEASING HORMONE; CLONIDINE; SOMATOSTATIN; YOUNG DOG; OLD DOG;

D O I：

10.1016/0006-8993(90)90386-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of acute administration of growth hormone-releasing hormone (GHRH), clonidine (CLO), an alleged GHRH releaser, or GHRH and clonidine given simultaneously was studied in young and old dogs. Simultaneous administration of CLO induced in young dogs an additive effect on GH release and potentiated in old dogs the GHRH-induced GH release, with the GH response being clearly higher than the sum of the GH responses to GHRH and CLO alone. These data suggest that CLO promotes GH releases in the dog also by inhibition of somatostatin release.

引用

页码：359 / 362

页数：4

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