INVOLVEMENT OF 2ND MESSENGERS AND PROTEIN-PHOSPHORYLATION IN ASTROCYTE SWELLING

被引：17

作者：

BENDER, AS

NEARY, JT

NORENBERG, MD

机构：

[1] VET ADM MED CTR,NEUROPATHOL LAB,MIAMI,FL 33101

[2] UNIV MIAMI,JACKSON MEM HOSP,SCH MED,DEPT PATHOL,MIAMI,FL 33101

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 1992年 / 70卷

关键词：

ASTROCYTE; CA-2+-DEPENDENT PROTEIN KINASES; CA-2+ INFLUX; CELL VOLUME; CYCLIC AMP; INOSITOL PHOSPHATES; PROTEIN PHOSPHORYLATION;

D O I：

10.1139/y92-284

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In a hypoosmotic model of astrocyte swelling, we found that Ca2+ and intracellular signals such as diacylglycerol and inositol phosphate, as well as protein phosphorylation systems, are implicated in the generation and (or) modulation of volume regulatory processes. Cyclic AMP, which also has a significant effect on astrocyte volume regulation, in addition influences some of these second messengers.

引用

页码：S362 / S366

页数：5

共 42 条

[1]

ALLISON AC, 1987, TRAUMATIC BRAIN EDEM, P65

[2] CALCIUM CALMODULIN-DEPENDENT PROTEIN-KINASE ACTIVITY IN PRIMARY ASTROCYTE CULTURES [J].