THE NATURE OF REED STERNBERG-LIKE CELLS IN CHRONIC LYMPHOCYTIC-LEUKEMIA

被引：30

作者：

TSANG, WYW ^{[1
]}

CHAN, JKC ^{[1
]}

NG, CS ^{[1
]}

机构：

[1] CARITAS MED CTR,HONG KONG,HONG KONG

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 1993年 / 99卷 / 03期

关键词：

CHRONIC LYMPHOCYTIC LEUKEMIA; HODGKINS DISEASE; REED-STERNBERG CELLS;

D O I：

10.1093/ajcp/99.3.317

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

In biopsy specimens of B-cell chronic lymphocytic leukemia, large cells with cytologic features of Reed-Sternberg cells and mononuclear Hodgkin's cells are an uncommon occurrence. The nature of these large cells has not been fully elucidated, and the relationship of these cases with Hodgkin's disease is unclear. Immunophenotypic analysis of a case of chronic lymphocytic leukemia with interspersed Reed-Sternberg cells showed that the large cells were positive for CD45 (LCA), various B-cell markers (CD19, CD20, CD22), and CD30 (Ki-1), but were negative for CD15 (Leu-M1), suggesting that they represented activated neoplastic B cells. These results were compared with those reported in the literature.

引用

页码：317 / 323

页数：7

共 34 条

[1]

BERNARD DJ, 1991, CANCER, V67, P997, DOI 10.1002/1097-0142(19910215)67:4<997::AID-CNCR2820670423>3.0.CO

[2]

2-L

[3] HODGKINS-DISEASE VARIANT OF RICHTERS SYNDROME - REPORT OF 8 CASES [J].