PULMONARY DRUG-DELIVERY OF FINE AEROSOL-PARTICLES FROM SUPERCRITICAL FLUIDS

被引：12

作者：

HYBERTSON, BM ^{[1
]}

REPINE, JE ^{[1
]}

BEEHLER, CJ ^{[1
]}

RUTLEDGE, KS ^{[1
]}

LAGALANTE, AF ^{[1
]}

SIEVERS, RE ^{[1
]}

机构：

[1] UNIV COLORADO,HLTH SCI CTR,WEBB WARING INST BIOMED RES,DENVER,CO 80262

来源：

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG | 1993年 / 6卷 / 04期

关键词：

DRUG AEROSOL; DRUG DELIVERY; VITAMIN-E; RAT; SUPERCRITICAL FLUID;

D O I：

10.1089/jam.1993.6.275

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Better methods for delivery of pharmacologic agents directly to and via the lung are needed. We found that a solution of alpha-tocopherol (vitamin E) dissolved in supercritical carbon dioxide formed 0.3 to 3 mum diameter droplets when the solution was allowed to expand through a restrictor nozzle. The decompressed aerosol stream was diluted with gaseous oxygen and directly administered to rats for 10 to 30 min via inhalation. These treatments resulted in significant increases in the lung vitamin E levels of the rats. The supercritical fluid drug delivery (SFDD) method holds potential for pulmonary delivery of many other drugs.

引用

页码：275 / 286

页数：12

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