GLUTAMATE RECEPTORS OF DROSOPHILA-MELANOGASTER - CLONING OF A KAINATE-SELECTIVE SUBUNIT EXPRESSED IN THE CENTRAL-NERVOUS-SYSTEM

被引：64

作者：

ULTSCH, A ^{[1
]}

SCHUSTER, CM ^{[1
]}

LAUBE, B ^{[1
]}

SCHLOSS, P ^{[1
]}

SCHMITT, B ^{[1
]}

BETZ, H ^{[1
]}

机构：

[1] MAX PLANCK INST HIRNFORSCH, NEUROCHEM ABT, DEUTSCHORDENSTR 46, W-6000 FRANKFURT 71, GERMANY

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 21期

关键词：

NEUROTRANSMITTER; LIGAND-GATED ION CHANNELS; XENOPUS OOCYTES; DROSOPHILA DEVELOPMENT; INVERTEBRATE;

D O I：

10.1073/pnas.89.21.10484

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report the isolation and functional characterization of cDNAs encoding a Drosophila kainate-selective glutamate receptor. The deduced mature 964-residue protein (DGluR-I) is 108,482 Da and exhibits significant homology to mammalian glutamate receptor subunits. Injection of DGluR-I cRNA into Xenopus oocytes generated kainate-operated ion channels which were blocked by the selective non-N-methyl-D-aspartate receptor antagonist 6-cyano-7-nitro-quinoxaline-2,3-dione and philanthotoxin. DGluR-I transcripts are differentially expressed during Drosophila development and, in late embryogenesis, accumulate in the central nervous system.

引用

页码：10484 / 10488

页数：5

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