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SELECTIVE BREEDING FOR ALCOHOL PREFERENCE AND ASSOCIATED RESPONSES

被引：268
作者：
LI, TK
LUMENG, L
DOOLITTLE, DP
机构：
[1] VAMC, INDIANAPOLIS, IN 46202 USA
[2] JACKSON LAB, BAR HARBOR, ME 04609 USA
来源：
BEHAVIOR GENETICS | 1993年 / 23卷 / 02期
关键词：
ALCOHOL SELF-ADMINISTRATION; ETHANOL REINFORCEMENT; TOLERANCE; SEROTONIN; DOPAMINE;
D O I：
10.1007/BF01067421
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Selective breeding for high and low alcohol-drinking preference has produced rat lines useful for studying the nature of excessive alcohol-seeking behavior. Compared with the alcohol-nonpreferring line, the preferring animals exhibit heightened responsivity to the low-dose activating effects of ethanol as well as enhanced capacity for developing tolerance to the aversive, behaviorally impairing effects of ethanol. The preferring animals exhibit lower brain serotonin and dopamine neurotransmitter activity as well as differences in other neurotransmitter neuromodulator systems, compared with the alcohol-nonpreferring animals.
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页码：163 / 170
页数：8
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