NUCLEOPHILIC PHOSPHATE-CATALYZED DEGRADATION OF PENICILLINS - DEMONSTRATION OF A PENICILLOYL PHOSPHATE INTERMEDIATE AND TRANSFORMATION OF AMPICILLIN TO A PIPERAZINEDIONE

被引：21

作者：

BUNDGAARD, H ^{[1
]}

HANSEN, J ^{[1
]}

机构：

[1] ROYAL DANISH SCH PHARM,DEPT PHARMACEUT,DK-2100 COPENHAGEN O,DENMARK

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1981年 / 9卷 / 04期

关键词：

D O I：

10.1016/0378-5173(81)90031-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：273 / 283

页数：11

共 31 条

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BLAHA, JM ;

KNEVEL, AM ;

KESSLER, DP ;

MINCY, JW ;

HEM, SL .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1976, 65 (08) :1165-1170

[2]

BUNDGAARD H, 1977, ACTA PHARM SUEC, V14, P67

[3] PIPERAZINEDIONE FORMATION FROM REACTION OF AMPICILLIN WITH CARBOHYDRATES AND ALCOHOLS IN AQUEOUS-SOLUTION [J].

BUNDGAARD, H ;

LARSEN, C .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1979, 3 (01) :1-11

[4] PHARMACEUTICAL ASPECTS OF PENICILLIN ALLERGY - POLYMERIZATION OF PENICILLINS AND REACTIONS WITH CARBOHYDRATES [J].

BUNDGAARD, H .

JOURNAL OF CLINICAL AND HOSPITAL PHARMACY, 1980, 5 (02) :73-96

[5] KINETICS AND MECHANISM OF SUCROSE-ACCELERATED DEGRADATION OF PENICILLINS IN AQUEOUS-SOLUTION [J].

BUNDGAARD, H ;

LARSEN, C .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1978, 1 (02) :95-104

[6]

BUNDGAARD H, 1976, ACTA PHARM SUEC, V13, P299

[7]

BUNDGAARD H, 1970, Dansk Tidsskrift for Farmaci, V44, P365

[8]

BUNDGAARD H, 1980, ARCH PHARM CHEM SCI, V8, P161

[9]

BUNDGAARD H, 1978, ARCH PHARMACI CHEM S, V6, P184

[10]

Bundgaard H., 1976, ARCH PHARM CHEM SCI, V4, P25

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