LYMPHOMATOID PAPULOSIS FOLLOWED BY LARGE-CELL LYMPHOMA - IMMUNOPHENOTYPICAL AND GENOTYPIC ANALYSIS

被引：45

作者：

KAUDEWITZ, P ^{[1
]}

HERBST, H ^{[1
]}

ANAGNOSTOPOULOS, I ^{[1
]}

ECKERT, F ^{[1
]}

BRAUNFALCO, O ^{[1
]}

STEIN, H ^{[1
]}

机构：

[1] FREE UNIV BERLIN,KLINIKUM STEGLITZ,INST PATHOL,W-1000 BERLIN 45,GERMANY

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1991年 / 124卷 / 05期

关键词：

D O I：

10.1111/j.1365-2133.1991.tb00627.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The immunophenotype and genotype of atypical cells in skin and lymph node infiltrates were investigated in a patient with lymphomatoid papulosis (LyP) complicated by anaplastic large-cell lymphoma of the lymph nodes. The large atypical cells in both skin and lymph nodes displayed an almost identical immunophenotype, i.e. CD30+ and CD25+. Southern blot analysis for T-cell receptor beta-chain gene rearrangement revealed an identical gene configuration in DNA extracted from skin and lymph node. Our results strongly support the hypothesis that clonal populations of T cells arising in cutaneous LyP lesions may undergo malignant transformation, spread into regional lymph nodes, and give rise to secondary malignant lymphomas, such as anaplastic large-cell lymphoma.

引用

页码：465 / 469

页数：5

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