A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF THYMOSTIMULIN IN SYMPTOMATIC HIV-INFECTED PATIENTS

被引:5
作者
BEALL, G
KRUGER, S
MORALES, F
IMAGAWA, D
GOLDSMITH, JA
FISHER, D
STEINBERG, J
PHAIR, J
WHALING, S
BITRAN, J
机构
[1] UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,DEPT PEDIAT,TORRANCE,CA 90502
[2] NORTHWESTERN UNIV,SCH MED,DEPT MED,CHICAGO,IL 60611
关键词
AIDS; AIDS-related complex; therapeutic trials; thymic hormones; thymostimulin;
D O I
10.1097/00002030-199007000-00012
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The potential therapeutic efficacy of the thymic hormone preparation, thymostimulin (TP1), in HIV infection has been studied in a multi-institutional, randomized, double-blind, placebo-controlled trial. Fifty evaluable patients with advanced AIDS-related complex (ARC) were injected with TP1 or placebo twice weekly for 6 months after 2 weeks of daily injections. The primary endpoint, progression to AIDS, was reached in nine TP1- and 11 placebo-treated subjects after 1 year. CD4 cell numbers were not affected by administration of the study drug. No toxicity was associated with TP1 treatment. We conclude that TP1 is ineffective in altering the progress of HIV disease in patients with advanced ARC.
引用
收藏
页码:679 / 681
页数:3
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