LIPID INTERACTION OF TETANUS NEUROTOXIN - A CALORIMETRIC AND FLUORESCENCE SPECTROSCOPY STUDY

被引：14

作者：

CALAPPI, E

MASSERINI, M

SCHIAVO, G

MONTECUCCO, C

TETTAMANTI, G

机构：

[1] UNIV MILAN,DEPT MED CHEM & BIOCHEM,VIA SALDINI 30,I-20133 MILAN,ITALY

[2] UNIV PADUA,INST GEN PATHOL,I-35100 PADUA,ITALY

来源：

FEBS LETTERS | 1992年 / 309卷 / 02期

关键词：

TETANUS TOXIN; GANGLIOSIDE MICRODOMAIN;

D O I：

10.1016/0014-5793(92)81074-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction of Tetanus toxin with phospholipid vesicles containing gangliosides (GD1a, GD1b or GT1b) or phosphatidic acid has been investigated at neutral or acidic pH. Change in the thermotropic properties of the vesicles occurred only after addition of the toxin at acidic pH, and led to surface binding or membrane insertion of the protein, dependent on the physical state of the membrane. Most remarkably, toxin addition at acidic pH to dipalmitoyl-phosphatidylcholine vesicles containing GT1b ganglioside, caused formation of ganglioside microdomains on the vesicle surface.

引用

页码：107 / 110

页数：4

共 24 条

[1] TETANUS TOXIN FRAGMENT FORMS CHANNELS IN LIPID VESICLES AT LOW PH [J].