BIOLOGICAL-ACTIVITIES OF P53 MUTANTS IN BURKITTS-LYMPHOMA CELLS

被引：28

作者：

VOUSDEN, KH

CROOK, T

FARRELL, PJ

机构：

[1] Ludwig Institute for Cancer Research, St Mary's Hospital Medical School, London W2 lPG, Norfolk Place

来源：

JOURNAL OF GENERAL VIROLOGY | 1993年 / 74卷

关键词：

D O I：

10.1099/0022-1317-74-5-803

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Wild-type human p53 and a series of p53 point mutants isolated from Burkitt's lymphoma (BL) cell lines were tested for their ability to inhibit DNA synthesis in a p53-negative BL cell line and to bind and be degraded by the human papillomavirus type 16 E6 protein. All the mutants lost the wild-type ability to inhibit DNA synthesis, demonstrating that they are all functionally altered. Binding to E6 and consequent degradation of the p53 mutants frequently correlated with changed suppressor properties in BL cells.

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页码：803 / 810

页数：8

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