SYNTHESIS AND CHARACTERIZATION OF COUMARIN-CROWN ETHERS

Improving the preparation methods of some common dihydroxycoumarins, coumarin derivatives of the macrocyclic ethers were obtained in good yields. Dihydroxycoumarins reacted with dichlorides or ditosylates of polyethyleneglycols in the presence of DMF/H2O/K2CO3 and macrocyclic ethers with a coumarin moiety were obtained with satisfactory yields. The structures of molecules obtained were proved with common methods of NMR, EI mass spectra and elemental analysis. Optical properties in acetonitrile and the association constants, K(a) of Na+ ion with such molecules were now determined in water with a Na+ ion selective electrode.