MORPHOLOGY OF POPLITEAL LYMPH-NODE RESPONSES IN BROWN-NORWAY RATS

被引:17
作者
BROULAND, JP
VERDIER, F
PATRIARCA, C
VIAL, T
DESCOTES, J
机构
[1] FAC MED ALEXIS CARREL,IMMUNOTOXICOL FONDAMENTALE & CLIN LAB,INSERM,U80,F-69008 LYON,FRANCE
[2] PHARMAKON EUROPE,ARBRESLE,FRANCE
来源
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH | 1994年 / 41卷 / 01期
关键词
D O I
10.1080/15287399409531829
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The popliteal lymph node (PLN) assay has been proposed as a tool to predict in rodents those xenobiotics likely to induce autoimmune reactions in humans. To further validate this assay and to study the mechanisms involved, histologic changes in PLNs from rats injected with streptozotocin, diphenylhydantoin, pure acetone, or 50% ethanol were compared to a local graft-versus-host (GvH) reaction. This study suggests that routine histology of PLNs is instrumental to discard primary irritants. In addition, the hypothesis of a GvH-like mechanism in positive PLN responses is supported by the finding that the reference compounds streptozotocin and diphenylhydantoin produced histologic changes similar to a ''true'' local GvH reaction.
引用
收藏
页码:95 / 108
页数:14
相关论文
共 20 条
[1]   DRUG-RELATED LUPUS - INCIDENCE, MECHANISMS AND CLINICAL IMPLICATIONS [J].
ADAMS, LE ;
HESS, EV .
DRUG SAFETY, 1991, 6 (06) :431-449
[2]   SKIN SENSITIZATION - A CRITICAL-REVIEW OF PREDICTIVE TEST METHODS IN ANIMALS AND MAN [J].
BOTHAM, PA ;
BASKETTER, DA ;
MAURER, T ;
MUELLER, D ;
POTOKAR, M ;
BONTINCK, WJ .
FOOD AND CHEMICAL TOXICOLOGY, 1991, 29 (04) :275-286
[3]  
DEBAKKER JM, 1990, VIRCHOWS ARCH B, V58, P279
[5]  
DESCOTES J, 1993, IN PRESS MODERN METH
[6]   A LYMPH NODE WEIGHT ASSAY FOR GRAFT-VERSUS-HOST ACTIVITY OF RAT LYMPHOID CELLS [J].
FORD, WL ;
BURR, W ;
SIMONSEN, M .
TRANSPLANTATION, 1970, 10 (03) :258-&
[7]   GRAFT-VERSUS-HOST REACTIONS - CLUES TO THE ETIOPATHOLOGY OF A SPECTRUM OF IMMUNOLOGICAL DISEASES [J].
GLEICHMANN, E ;
PALS, ST ;
ROLINK, AG ;
RADASZKIEWICZ, T ;
GLEICHMANN, H .
IMMUNOLOGY TODAY, 1984, 5 (11) :324-332
[8]   STUDIES ON THE MECHANISM OF DRUG SENSITIZATION - T-CELL-DEPENDENT POPLITEAL LYMPH-NODE REACTION TO DIPHENYLHYDANTOIN [J].
GLEICHMANN, H .
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1981, 18 (02) :203-211
[9]  
JOSEPH X, 1988, TOXICOLOGIST, V8, P43
[10]   THE POPLITEAL LYMPH-NODE ASSAY IN MICE TO SCREEN FOR THE IMMUNE DISREGULATING POTENTIAL OF CHEMICALS - A PRELIMINARY-STUDY [J].
KAMMULLER, ME ;
THOMAS, C ;
DEBAKKER, JM ;
BLOKSMA, N ;
SEINEN, W .
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1989, 11 (03) :293-300