CHARACTERIZATION OF ULTRAVIOLET LIGHT-INDUCED RELAXATION OF THE ISOLATED DUODENUM OF THE RAT

被引：7

作者：

DAVE, KC ^{[1
]}

JINDAL, MN ^{[1
]}

KELKAR, VV ^{[1
]}

TRIVEDI, HD ^{[1
]}

机构：

[1] BJ MED COLL,DEPT PHARMACOL,AHMEDABAD 380016,INDIA

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1979年 / 66卷 / 02期

关键词：

D O I：

10.1111/j.1476-5381.1979.tb13665.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Isolated duodenum of the rat, exposed to ultraviolet (u.v.) light in the presence of NO2 ions, responded with reversible relaxation. The photorelaxation response did not seem to involve any known receptor mechanisms and was independent of any ganglionic or neuronal influences. Changes in the ionic environment of the tissue showed that Na+ and Ca2+ were essential for the photorelaxation. K+ depolarized‐tissue did not show the photoresponse. The presence of the metabolic inhibitors, iodoacetic acid, 2,4‐dinitrophenol, sodium fluoride, sodium azide or potassium cyanide, abolished the photorelaxation response. It is proposed that the photorelaxation of the tissue resulted from the liberation of metabolic energy following NO2 ion‐dependent absorption of u.v. light energy, which in turn, interfered with the Na+ ion movement across the cell membrane. 1979 British Pharmacological Society

引用

页码：197 / 201

页数：5

共 18 条

[1] The light effect on the surviving smooth muscle organs. [J].