DNA-SEQUENCE POLYMORPHISMS IN ALU REPEATS

被引：124

作者：

ORITA, M ^{[1
]}

SEKIYA, T ^{[1
]}

HAYASHI, K ^{[1
]}

机构：

[1] NATL CANC CTR,RES INST,DIV ONCOGENE,1-1 TSUKIJI 5 CHOME,CHUO KU,TOKYO 104,JAPAN

来源：

GENOMICS | 1990年 / 8卷 / 02期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1016/0888-7543(90)90282-Y

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have developed an efficient method for detection of sequence differences in genomic DNA based on a new principle (M. Orita et al., 1989, Genomics 5: 874-879). Using this method, we show here that approximately half the Alu repeats interspersed in the human genome are significantly polymorphic. Analysis of Alu repeat polymorphism should be useful in construction of a high-resolution map and also in identifying genotypes of individuals for clinical and other purposes because the repeats are ubiquitous and the technique for their detection is simple. © 1990.

引用

页码：271 / 278

页数：8

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