THE STEADY-STATE AMINO-ACID FLUXES ACROSS THE PERFUSED CHOROID-PLEXUS OF THE SHEEP

被引:36
作者
PRESTON, JE [1 ]
SEGAL, MB [1 ]
机构
[1] UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,SHERRINGTON SCH PHYSIOL,ST THOMASS CAMPUS,LONDON SE1 7EH,ENGLAND
基金
英国惠康基金;
关键词
Amino acids; Basolateral; Choroid plexus; CSF; Sheep;
D O I
10.1016/0006-8993(90)90874-B
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The steady-state flux of labelled amino acids was investigated across the isolated perfused choroid plexus of the sheep. The extraction of anionic, cationic, small and large neutral amino acids by the blood side of the choroid plexus was demonstrated. However, there was no uptake of the analogue MeAIB, confirming the absence of the 'A' carrier system on this side of the blood-CSF barrier. The direction of the net flux of amino acids across the tissue varied depending on the amino acid and its concentration. At a concentration of 0.01 mM the net movement for phenylalanine, serine, aspartate and glycine was from blood to CSF. When the concentration of amino acid was increased to 0.1 mM, the net flux of phenylalanine and serine remained from blood to CSF whereas the net flux of the transmitters, aspartate and glycine, was in the opposite direction, from CSF to blood. When the level was raised further, to 1 mM, all four amino acids showed a net CSF to blood flux. The concentration of amino acids is newly formed CSF was calculated from the blood to CSF fluxes and was found to be between 2 and 200 μM, similar to that found in mammalian bulk phase CSF. © 1990.
引用
收藏
页码:275 / 279
页数:5
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