PHYSIOLOGICAL SURFACTANTS AFFECTING PERMEATION AND BSL LOWERING IN RABBIT FROM GLIBENCLAMIDE TABLETS

被引：4

作者：

SINGH, J

SINGH, S

机构：

[1] Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1990年 / 16卷 / 14期

关键词：

D O I：

10.3109/03639049009023649

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The physiologic surfactants (e.g. sodium taurocholate and sodium tauroglycocholate) were included in the tablet formulations to increase the solubility, permeability and absorption of glibenclamide. Sodium tauroglycocholate was found to increase the permeation, AUC, Cmaxl and % Frel with its increasing concentrations in tablets. Sodium taurocholate, at submicellar level, had increased the permeation, AUC, Cmaxl and % Frel and decreased the above parameters beyond critical micelle concentration. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：2193 / 2198

页数：6