CELL-CYCLE-REGULATED EXPRESSION OF THYMOSIN-BETA-4 IN THYMOCYTES

被引：31

作者：

SCHOBITZ, B ^{[1
]}

NETZKER, R ^{[1
]}

HANNAPPEL, E ^{[1
]}

BRAND, K ^{[1
]}

机构：

[1] UNIV ERLANGEN NURNBERG,FAK MED,INST BIOCHEM,FAHRSTR 17,W-8520 ERLANGEN,GERMANY

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1991年 / 199卷 / 02期

关键词：

D O I：

10.1111/j.1432-1033.1991.tb16118.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thymosin beta-4 belongs to a family of ubiquitous peptides present at a high cellular content but still with an unknown intracellular function. The expression of this peptide was studied in concanavalin-A-stimulated, proliferating rat thymocytes during cell cycle progression. An early, transient 10-fold increase of the peptide occurred 1 h after stimulation without elevation of the corresponding mRNA level. This increase coincided with that of thymosin beta-4 biosynthesis. The sharp decline of the thymosin beta-4 content was not due to a secretion of the peptide into the medium. During S phase and mitosis, the biosynthetic rates as well as mRNA content, but not the cellular thymosin beta-4 concentration, increased again. After 96 h of culture the values returned to those of quiescent cells.

引用

页码：257 / 262

页数：6

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