EFFECT OF INTERLEUKIN-6 ON PHENOBARBITAL INDUCTION OF CYTOCHROME-P-450IIB IN CULTURED RAT HEPATOCYTES

被引：56

作者：

WILLIAMS, JF

BEMENT, WJ

SINCLAIR, JF

SINCLAIR, PR

机构：

[1] VET ADM MED CTR,WHITE RIVER JCT,VT 05009

[2] DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT BIOCHEM,HANOVER,NH 03756

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 178卷 / 03期

关键词：

D O I：

10.1016/0006-291X(91)90998-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human recombinant interleukin 6 (rhIL-6) caused a dose dependent decrease in the phenobarbital induction of benzyloxyresorufin O-deethylase activity in cultured rat hepatocytes. Decreased enzymatic activity was associated with a decrease in the amount of immunoreactive P-450IIB 1 2. rhIL-6 also prevented the PB-induced increase in the steady state level of P-450IIB mRNA. These results suggest that altered P-450 levels observed in vivo during the acute phase reaction may be due to interleukin 6. © 1991.

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页码：1049 / 1055

页数：7

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