EFFECT OF INTERLEUKIN-6 ON PHENOBARBITAL INDUCTION OF CYTOCHROME-P-450IIB IN CULTURED RAT HEPATOCYTES

被引:56
作者
WILLIAMS, JF
BEMENT, WJ
SINCLAIR, JF
SINCLAIR, PR
机构
[1] VET ADM MED CTR,WHITE RIVER JCT,VT 05009
[2] DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT BIOCHEM,HANOVER,NH 03756
关键词
D O I
10.1016/0006-291X(91)90998-M
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Human recombinant interleukin 6 (rhIL-6) caused a dose dependent decrease in the phenobarbital induction of benzyloxyresorufin O-deethylase activity in cultured rat hepatocytes. Decreased enzymatic activity was associated with a decrease in the amount of immunoreactive P-450IIB 1 2. rhIL-6 also prevented the PB-induced increase in the steady state level of P-450IIB mRNA. These results suggest that altered P-450 levels observed in vivo during the acute phase reaction may be due to interleukin 6. © 1991.
引用
收藏
页码:1049 / 1055
页数:7
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