OVERNIGHT (1 MG) DEXAMETHASONE SUPPRESSION TESTING RELIABLY DISTINGUISHES NON-CUSHINGOID OBESITY FROM CUSHINGS-SYNDROME

被引：14

作者：

FOK, ACK

TAN, KT

JACOB, E

SUM, CF

机构：

[1] Department of Medicine I (Endocrinology), Singapore General Hospital

[2] epartment of Clinical Biochemistry, Singapore General Hospital

来源：

STEROIDS | 1991年 / 56卷 / 11期

关键词：

STEROID; DEXAMETHASONE SUPPRESSION TEST; CORTISOL; OBESITY; CUSHINGS SYNDROME;

D O I：

10.1016/0039-128X(91)90011-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To determine the sensitivity of the overnight 1-mg dexamethasone suppression test in diagnosing Cushing's syndrome, we evaluated the cortisol responses of 55 subjects (25 non-obese individuals with body mass index < 25 kg/m2, 20 obese individuals with body mass index > 30 kg/m2, and 10 patients with surgically proven Cushing's syndrome) following ingestion of 1 mg dexamethasone at midnight. The basal 8 AM plasma cortisol levels among non-obese and obese individuals and patients with Cushing's syndrome were 310 +/- 85, 377 +/- 91, and 813 +/- 270 nmol/L, respectively. Following 1 mg of dexamethasone, Cushing's syndrome patients showed minimal suppression of cortisol to 609 +/- 180 nmol/L (P = 0.79). Non-obese and obese individuals suppressed to 18.7 +/- 6.0 nmol/L (P < 0.001) and 22 +/- 7.1 nmol/L (P = 0.003), respectively. The results demonstrated similar cortisol responses to overnight dexamethasone suppression in obese and non-obese groups, and clearly distinguished these subjects from those with Cushing's syndrome. Obesity is not a confounding factor in the 1-mg dexamethasone suppression test.

引用

页码：549 / 551

页数：3

共 12 条

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