NEUROPEPTIDE-Y MESSENGER-RNA REGULATION IN RAT SYMPATHETIC-GANGLIA - EFFECT OF RESERPINE

被引：23

作者：

HANZE, J

KUMMER, W

HAASS, M

LANG, RE

机构：

[1] UNIV MARBURG,DEPT PHYSIOL & PATHOPHYSIOL,DEUTSCHHAUSSTR 2,W-3550 MARBURG,GERMANY

[2] UNIV HEIDELBERG,DEPT ANAT,W-6900 HEIDELBERG,GERMANY

[3] UNIV HEIDELBERG,DEPT CARDIOL,W-6900 HEIDELBERG,GERMANY

来源：

NEUROSCIENCE LETTERS | 1991年 / 124卷 / 01期

关键词：

NEUROPEPTIDE-Y; MESSENGER RNA; SYMPATHETIC GANGLIA; RESERPINE;

D O I：

10.1016/0304-3940(91)90836-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To study the mechanism underlying trans-synaptic neuropeptide regulation, mRNA levels of neuropeptide Y were examined in the rat stellate and superior cervical ganglia using a specific neuropeptide Y cRNA probe. Basal levels of neuropeptide Y mRNA were detectable in total RNA extracts from single ganglia. Reserpine induced a large rise in ganglion neuropeptide Y mRNA. Decentralization prevented the increase of neuropeptide Y mRNA content in the ganglia. This suggests that the reserpine induced increase in neuropeptide Y mRNA was dependent on transsynaptic stimulation. Consequently, neuropeptide mRNA levels in sympathetic ganglia may be under the control of preganglionic impulse flow.

引用

页码：119 / 121

页数：3

共 13 条

[1] MOLECULAR-STRUCTURE OF MAMMALIAN NEUROPEPTIDE-Y - ANALYSIS BY MOLECULAR-CLONING AND COMPUTER-AIDED COMPARISON WITH CRYSTAL-STRUCTURE OF AVIAN HOMOLOG [J].