SOLUBILITY OF THEOPHYLLINE IN AQUEOUS N,N-DIMETHYLFORMAMIDE MIXTURES

被引：7

作者：

GONZALEZ, AG

HERRADOR, MA

ASUERO, AG

机构：

[1] Department of Analytical Chemistry University of Seville Scville

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 108卷 / 02期

关键词：

SOLUBILITY PREDICTION; EXTENDED HILDEBRAND SOLUBILITY APPROACH; THEOPHYLLINE; AQUEOUS N; N-DIMETHYLFORMAMIDE MIXTURE;

D O I：

10.1016/0378-5173(94)90326-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The solubilities of theophylline in several water-N,N-dimethylformamide mixtures have been determined and found to show non-regular behaviour. The results were treated on the basis of the extended Hildebrand solubility approach, considering interaction terms. An equation has been obtained for predicting the solubility of theophylline in N,N-dimethylformamide, water and their mixtures, allowing the interpolation of new or missing solubilities in these blends.

引用

收藏

页码：149 / 154

页数：6

相关论文

共 15 条

[1]

AKHNAZAROVA S, 1984, EXPT OPTIMIZATION CH, P123

[2] SOLUBILITY PARAMETERS [J].

BARTON, AFM .

CHEMICAL REVIEWS, 1975, 75 (06) :731-753

[3] THERMODYNAMIC PROPERTIES OF LIQUID-MIXTURES .2. DIMETHYLFORMAMIDE WATER [J].

CILENSE, M ;

BENEDETTI, AV ;

VOLLET, DR .

THERMOCHIMICA ACTA, 1983, 63 (02) :151-156

[4] METHOD FOR ESTIMATING BOTH SOLUBILITY PARAMETERS AND MOLAR VOLUMES OF LIQUIDS [J].

FEDORS, RF .

POLYMER ENGINEERING AND SCIENCE, 1974, 14 (02) :147-154

[5] EVALUATION OF SOLVENT EFFECTS ON THE DISSOCIATION OF ALIPHATIC CARBOXYLIC-ACIDS IN AQUEOUS N,N-DIMETHYLFORMAMIDE MIXTURES ACCORDING TO THE SCALED PARTICLE THEORY [J].

GONZALEZ, AG ;

ROSALES, D ;

ARIZA, JLG ;

SANZ, JF .

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 1991, 4 (02) :87-95

[6] SOLVENT EFFECTS ON THE DISSOCIATION OF ALIPHATIC CARBOXYLIC-ACIDS IN WATER-N,N-DIMETHYLFORMAMIDE MIXTURES [J].

GONZALEZ, AG ;

ROSALES, D ;

GOMEZARIZA, JL ;

SANZ, JF .

ANALYTICA CHIMICA ACTA, 1990, 228 (02) :301-306

[7]

James KC, 1986, SOLUBILITY RELATED P, p[149, 213]

[8]

MAHMOOD AJ, 1977, J BANGLADESH ACAD SC, V1, P105

[9] EXTENDED HILDEBRAND SOLUBILITY APPROACH AND THE LOG LINEAR SOLUBILITY EQUATION [J].

MARTIN, A ;

WU, PL ;

ADJEI, A ;

LINDSTROM, RE ;

ELWORTHY, PH .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1982, 71 (08) :849-856

[10] EXTENDED HILDEBRAND SOLUBILITY APPROACH - TESTOSTERONE AND TESTOSTERONE PROPIONATE IN BINARY SOLVENTS [J].

MARTIN, A ;

WU, PL ;

ADJEI, A ;

MEHDIZADEH, M ;

JAMES, KC ;

METZLER, C .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1982, 71 (12) :1334-1340