SYNTHESIS OF A [C-11] METHOXY DERIVATIVE OF ALPHA-DIHYDROTETRABENAZINE - A RADIOLIGAND FOR STUDYING THE VESICULAR MONOAMINE TRANSPORTER

被引：24

作者：

DASILVA, JN ^{[1
]}

KILBOURN, MR ^{[1
]}

MANGNER, TJ ^{[1
]}

机构：

[1] UNIV MICHIGAN,MED CTR,DEPT INTERNAL MED,DIV NUCL MED,ANN ARBOR,MI 48109

来源：

APPLIED RADIATION AND ISOTOPES | 1993年 / 44卷 / 12期

关键词：

D O I：

10.1016/0969-8043(93)90103-H

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of [C-11]TBZOMe, a [C-11]methoxy derivative at the 2-hydroxy position of alpha-dihydrotetrabenazine, was carried out by an O-[C-11]methylation reaction. The product [C-11]TBZOMe (100-200 mCi) was obtained in 15-40% radiochemical yield (corrected for decay) within 37 min, and in high specific activity (2000-2500 Ci/mmol) and radio-chemical purity (>97%). [C-11]TBZOMe is a potential new radioligand for studying the vesicular monoamine transporter using positron emission tomography.

引用

页码：1487 / 1489

页数：3

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