SIMULATING THE PROCESS OF MALIGNANT TRANSFORMATION

被引：14

作者：

LUEBECK, EG

MOOLGAVKAR, SH

机构：

[1] Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA

来源：

MATHEMATICAL BIOSCIENCES | 1994年 / 123卷 / 02期

关键词：

D O I：

10.1016/0025-5564(94)90008-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A computationally efficient method for the simulation of carcinogenesis is presented. The underlying model for the process is the two-mutation clonal expansion model with explicit consideration of stochastic growth of malignant tumors. The usual likelihood-based methods of analysis ignore the growth kinetics of malignant tumors. The effect of this oversight on estimation of parameters is explored by simulation.

引用

页码：127 / 146

页数：20

共 27 条

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[Anonymous], 1986, NUMERICAL RECIPES

[2] DETERMINATION OF THE LENGTH OF THE HISTOLOGICAL STAGES OF APOPTOSIS IN NORMAL LIVER AND IN ALTERED HEPATIC FOCI OF RATS [J].