DNA MISMATCH REPAIR AND CANCER

被引：163

作者：

CHUNG, DC ^{[1
]}

RUSTGI, AK ^{[1
]}

机构：

[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT MED,GASTROINTESTINAL UNIT,BOSTON,MA 02114

来源：

GASTROENTEROLOGY | 1995年 / 109卷 / 05期

关键词：

D O I：

10.1016/0016-5085(95)90660-6

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The genetic basis of cancer involves certain classes of genes, particularly oncogenes, tumor-suppressor genes, and DNA mismatch repair genes. Originally identified in bacteria and yeast, the human homologues of DNA mismatch repair genes have been implicated in the pathogenesis of the hereditary nonpolyposis colorectal cancer syndromes, as well as a variety of different sporadic cancers. An appreciation of their role in cancer is predicated on an understanding of their function in the processes of DNA repair. This article reviews the recent developments and advances in the biology of the human DNA mismatch repair genes and their involvement in the pathogenesis of cancer.

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页码：1685 / 1699

页数：15

相关论文

共 109 条

[1]

AALTONEN LA, 1994, CANCER RES, V54, P1645

[2]

CLUES TO THE PATHOGENESIS OF FAMILIAL COLORECTAL-CANCER [J].

AALTONEN, LA ;

PELTOMAKI, P ;

LEACH, FS ;

SISTONEN, P ;

PYLKKANEN, L ;

MECKLIN, JP ;

JARVINEN, H ;

POWELL, SM ;

JEN, J ;

HAMILTON, SR ;

PETERSEN, GM ;

KINZLER, KW ;

VOGELSTEIN, B ;

DELACHAPELLE, A .

SCIENCE, 1993, 260 (5109) :812-816

[3]

THE SACCHAROMYCES-CEREVISIAE MSH2 PROTEIN SPECIFICALLY BINDS TO DUPLEX OLIGONUCLEOTIDES CONTAINING MISMATCHED DNA-BASE PAIRS AND INSERTIONS [J].

ALANI, E ;

CHI, NW ;

KOLODNER, R .

GENES & DEVELOPMENT, 1995, 9 (02) :234-247

[4]

[Anonymous], 1995, BIOCHEMISTRY-US

[5]

A MISMATCH RECOGNITION DEFECT IN COLON-CARCINOMA CONFERS DNA MICROSATELLITE INSTABILITY AND A MUTATOR PHENOTYPE [J].

AQUILINA, G ;

HESS, P ;

BRANCH, P ;

MACGEOCH, C ;

CASCIANO, I ;

KARRAN, P ;

BIGNAMI, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (19) :8905-8909

[6]

MALE-MICE DEFECTIVE IN THE DNA MISMATCH REPAIR GENE PMS2 EXHIBIT ABNORMAL CHROMOSOME SYNAPSIS IN MEIOSIS [J].

BAKER, SM ;

BRONNER, CE ;

ZHANG, L ;

PLUG, AW ;

ROBATZEK, M ;

WARREN, G ;

ELLIOTT, EA ;

YU, JA ;

ASHLEY, T ;

ARNHEIM, N ;

FLAVELL, RA ;

LISKAY, RM .

CELL, 1995, 82 (02) :309-319

[7]

MUTATOR PHENOTYPES IN HUMAN COLORECTAL-CARCINOMA CELL-LINES [J].

BHATTACHARYYA, NP ;

SKANDALIS, A ;

GANESH, A ;

GRODEN, J ;

MEUTH, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) :6319-6323

[8]

MOLECULAR THEMES IN ONCOGENESIS [J].

BISHOP, JM .

CELL, 1991, 64 (02) :235-248

[9]

LOCALIZATION OF THE GENE FOR FAMILIAL ADENOMATOUS POLYPOSIS ON CHROMOSOME-5 [J].

BODMER, WF ;

BAILEY, CJ ;

BODMER, J ;

BUSSEY, HJR ;

ELLIS, A ;

GORMAN, P ;

LUCIBELLO, FC ;

MURDAY, VA ;

RIDER, SH ;

SCAMBLER, P ;

SHEER, D ;

SOLOMON, E ;

SPURR, NK .

NATURE, 1987, 328 (6131) :614-616

[10]

CANCER GENETICS [J].

BODMER, WF .

BRITISH MEDICAL BULLETIN, 1994, 50 (03) :517-526

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