THE ESSENTIAL ROLE OF MICROSOMAL DEACETYLASE ACTIVITY IN THE METABOLIC-ACTIVATION, DNA (DEOXYGUANOSIN-8-YL)-2-AMINOFLUORENE ADDUCT FORMATION AND INITIATION OF LIVER-TUMORS BY N-HYDROXY-2-ACETYLAMINOFLUORENE IN THE LIVERS OF INFANT MALE B6C3F1 MICE

被引：41

作者：

LAI, CC ^{[1
]}

MILLER, EC ^{[1
]}

MILLER, JA ^{[1
]}

LIEM, A ^{[1
]}

机构：

[1] UNIV WISCONSIN,MCARDLE LAB CANC RES,SCH MED,MADISON,WI 53706

来源：

CARCINOGENESIS | 1988年 / 9卷 / 07期

关键词：

D O I：

10.1093/carcin/9.7.1295

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：1295 / 1302

页数：8

共 44 条

[1] METABOLIC ACTIVATION OF CARCINOGEN N-HYDROXY-N-2-ACETYLAMINOFLUORENE .3. OXIDATION WITH HORSERADISH PEROXIDASE TO YIELD 2-NITROSOFLUORENE AND N-ACETOXY-N-2-ACETYLAMINOFLUORENE [J].

BARTSCH, H ;

HECKER, E .

BIOCHIMICA ET BIOPHYSICA ACTA, 1971, 237 (03) :567-&

[2] ELECTROPHILIC N-ACETOXYAMINOARENES DERIVED FROM CARCINOGENIC N-HYDROXY-N-ACETYLAMINOARENES BY ENZYMATIC DEACETYLATION AND TRANSACETYLATION IN LIVER [J].

BARTSCH, H ;

DWORKIN, M ;

MILLER, JA ;

MILLER, EC .

BIOCHIMICA ET BIOPHYSICA ACTA, 1972, 286 (02) :272-298

[3] FORMATION OF ELECTROPHILIC N-ACETOXYARYLAMINES IN CYTOSOLS FROM RAT MAMMARY-GLAND AND OTHER TISSUES BY TRANSACETYLATION FROM CARCINOGEN N-HYDROXY-4-ACETYLAMINOBIPHENYL [J].

BARTSCH, H ;

DWORKIN, C ;

MILLER, EC ;

MILLER, JA .

BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 304 (01) :42-55

[4]

BELAND FA, 1980, CANCER RES, V40, P834

[5] AMINOFLUORENE-DNA ADDUCT FORMATION IN SALMONELLA-TYPHIMURIUM EXPOSED TO THE CARCINOGEN N-HYDROXY-2-ACETYLAMINOFLUORENE [J].

BERANEK, DT ;

WHITE, GL ;

HEFLICH, RH ;

BELAND, FA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (17) :5175-5178

[6] DNA-BINDING AND MUTATION SPECTRA OF THE CARCINOGEN N-2-AMINOFLUORENE IN ESCHERICHIA-COLI - A CORRELATION BETWEEN THE CONFORMATION OF THE PREMUTAGENIC LESION AND THE MUTATION SPECIFICITY [J].

BICHARA, M ;

FUCHS, RPP .

JOURNAL OF MOLECULAR BIOLOGY, 1985, 183 (03) :341-351

[7] ACTIVATION OF O-GLUCURONIDE OF CARCINOGEN N-HYDROXY-N-2-FLUORENYLACETAMIDE BY ENZYMATIC DEACETYLATION INVITRO - FORMATION OF FLUORENYLAMINE-TRANSFER-RNA ADDUCTS [J].

CARDONA, RA ;

KING, CM .

BIOCHEMICAL PHARMACOLOGY, 1976, 25 (09) :1051-1056

[8]

DEBAUN JR, 1968, P SOC EXP BIOL MED, V129, P268

[9]

DEBAUN JR, 1970, CANCER RES, V30, P577

[10] ACETYL COENZYME A-DEPENDENT METABOLIC-ACTIVATION OF N-HYDROXY-3,2'-DIMETHYL-4-AMINOBIPHENYL AND SEVERAL CARCINOGENIC N-HYDROXY ARYLAMINES IN RELATION TO TISSUE AND SPECIES-DIFFERENCES, OTHER ACYL DONORS, AND ARYLHYDROXAMIC ACID-DEPENDENT ACYLTRANSFERASES [J].

FLAMMANG, TJ ;

KADLUBAR, FF .

CARCINOGENESIS, 1986, 7 (06) :919-926

← 1 2 3 4 5 →