INCREASED ACTIVITY OF LYSOSOMAL ENZYMES IN HUMAN ATHEROSCLEROTIC AORTAS

被引：55

作者：

MILLER, BF

KOTHARI, HV

机构：

[1] Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 1969年 / 10卷 / 03期

关键词：

D O I：

10.1016/0014-4800(69)90058-6

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Beta-glucuronidase activity is known to increase in human atherosclerotic arteries. Since beta-glucuronidase is a key marker enzyme for lysosomal activity, it was decided to investigate the activity of other lysosomal enzymes. In intima-media homogenates of human atherosclerotic aortas there was found an increased total activity of cathepsin, suggestive evidence for acid phosphatase, and no change in arylsulfatase. Beta-glucuronidase showed the greatest increase in total activity. Besides showing these changes in total activity, all four enzymes exhibited definitely increased activity in the lysosomal fraction of the atherosclerotic aortas. © 1969.

引用

页码：288 / +

页数：1

共 28 条

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BRANWOOD AW, 1960, LANCET, V2, P1254

[2]

BREST AN, 1967, ATHEROSCLEROTIC V ED

[3]

CERIOTTI G, 1952, J BIOL CHEM, V198, P297

[4] MICRODETERMINATION OF PHOSPHORUS [J].