STUDIES DIRECTED TOWARD THE TOTAL SYNTHESIS OF 14-MEMBERED CYCLOPEPTIDE ALKALOIDS - SYNTHESIS OF A LINEAR PRECURSOR TO NUMMULARINE-F

被引：14

作者：

FLANAGAN, DM ^{[1
]}

JOULLIE, MM ^{[1
]}

机构：

[1] UNIV PENN,DEPT CHEM,PHILADELPHIA,PA 19104

来源：

SYNTHETIC COMMUNICATIONS | 1990年 / 20卷 / 03期

关键词：

D O I：

10.1080/00397919008052788

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Investigations leading to the synthesis of a linear precursor (2) to the 14-membered cyclopeptide alkaloid, nummularine-F, are described. The Ugi four-component condensation reaction was utilized to prepare the key intermediate (3) which, under mild conditions, was elaborated to 2. The attempted cyclization conditions all led to the formation of a 28-membered cyclopeptide. Copyright © 1990 by Taylor & Francis Group. All rights reserved.

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页码：459 / 467

页数：9

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