ACROMEGALY DUE TO PRODUCTION OF A GROWTH-HORMONE RELEASING FACTOR BY A BRONCHIAL CARCINOID TUMOR

被引：80

作者：

SHALET, SM

BEARDWELL, CG

MACFARLANE, IA

ELLISON, ML

NORMAN, CM

REES, LH

HUGHES, M

机构：

[1] WYTHENSHAWE HOSP,MANCHESTER M23 9LT,ENGLAND

[2] LUDWIG INST CANC RES,HUMAN CANC BIOL UNIT,LONDON,ENGLAND

[3] ST BARTHOLOMEWS HOSP,LONDON EC1A 7BE,ENGLAND

来源：

CLINICAL ENDOCRINOLOGY | 1979年 / 10卷 / 01期

关键词：

D O I：

10.1111/j.1365-2265.1979.tb03034.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have studied growth hormone production in a patient with a bronchial carcinoid and acromegaly. The absence of growth hormone from the carcinoid tumour was demonstrated by extraction, cell culture and immunoperoxidase techniques. Using a linked perfusion culture system, effluent from the bronchial carcinoid tumour culture stimulated a rapid release of growth hormone from a rat pituitary mono‐layer. This is the first time evidence of growth hormone releasing activity by a bronchial carcinoid has been demonstrated in a patient with the clinical and biochemical manifestations of excess growth hormone production. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：61 / 67

页数：7

共 26 条

[1] HYPERADRENOCORTICISM AND ACTH-RELEASING FACTOR [J].