TREATMENT OF POST-MENOPAUSAL OSTEOPOROSIS

Bone loss can be prevented by standard oestrogen replacement therapy and delayed by the administration of calcium supplements. The most suitable patients to treat are those with a raised urinary hydroxyproline or other evidence of rapid bone loss. Patients aged below 65 years with established osteoporosis, and in whom oestrogens are not contraindicated, will derive some benefit from oestrogen therapy. In those with malabsorption of calcium, vitamin D may be added to oestrogen therapy in a dose not exceeding 10,000 units daily or alternatively, small doses of one of the vitamin D metabolites, e.g. 1αOHD3 (alfacalcidol) 1μg daily, or 1,25(OH)2D3 (calcitriol) 0.5μg daily. In patients aged over 65 years, supplementary calcium (not less than 1000mg daily) is recommended. © 1979, ADIS Press Australasia Pty Ltd. All rights reserved.