BIOCHEMICAL-EVIDENCE OF THE ANTIGENIC CELL-SURFACE HETEROGENEITY OF LEISHMANIA-MEXICANA

被引：4

作者：

MANENTI, S ^{[1
]}

KUTNER, S ^{[1
]}

RASCON, A ^{[1
]}

HERNANDEZ, AG ^{[1
]}

机构：

[1] CENT UNIV VENEZUELA,FAC SCI,SCH BIOL,CARACAS 1041,VENEZUELA

来源：

PARASITOLOGY RESEARCH | 1990年 / 76卷 / 04期

关键词：

D O I：

10.1007/BF00928183

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

In the present study, an enzymatical and structural analysis of Leishmania mexicana cell-surface components was carried out, demonstrating that protease and acid phosphatase activities were present at the L. mexicana cell surface. These findings correlate with the expression of the main components detected on the surface of L. mexicana promastigotes: the 50-kDa component is responsible for the acid phosphatase activity, whereas glycoprotein 65 (gp65) was characterized as the structural polypeptide of the surface protease. Furthermore, the 50- and 65-kDa antigens were found to be structurally different, inasmuch as no homology was observed in their peptide digestion profiles. The results presented in this communication confirm heterogeneity in the expression of the surface components of L. mexicana promastigotes at both the structural and the biochemical level. © 1990 Springer-Verlag.

引用

页码：301 / 305

页数：5

共 34 条

[1] ACID-PHOSPHATASE ISOENZYME MAPPING IN LEISHMANIA [J].