CALCIUM-CHANNEL IN ISOLATED OUTER HAIR-CELLS OF GUINEA-PIG COCHLEA

被引：56

作者：

NAKAGAWA, T

KAKEHATA, S

AKAIKE, N

KOMUNE, S

TAKASAKA, T

UEMURA, T

机构：

[1] TOHOKU UNIV,SCH MED,DEPT OTORHINOLARYNGOL,SENDAI,MIYAGI 980,JAPAN

[2] KYUSHU UNIV,FAC MED,DEPT OTORHINOLARYNGOL,FUKUOKA 812,JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 125卷 / 01期

关键词：

OUTER HAIR CELL; GUINEA PIG; WHOLE-CELL VOLTAGE-CLAMP; CALCIUM CHANNEL;

D O I：

10.1016/0304-3940(91)90136-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The physiological and pharmacological properties of the Ca2+ channel in outer hair cells (OHCs) freshly isolated from guinea pig cochlea were investigated using a whole-cell patch-clamp technique. The Ca2+ current (I(Ca)) was activated from a membrane potential of -20 mV and reached peak value around +20 mV in external solution containing 20 mM Ca2+ at a holding potential of -70 mV. The peak amplitude of I(Ca) increased in a hyperbolic manner with increasing extracellular Ca2+ concentration. The ion selectively was Ba2+ > > Ca2+ greater-than-or-equal-to Sr2+. It was concluded that the Ca2+ channel in OHCs of guinea pig is of the L-type.

引用

页码：81 / 84

页数：4

共 28 条

[1] SEPARATION OF CURRENT-DEPENDENT AND VOLTAGE-DEPENDENT INACTIVATION OF CALCIUM CURRENT IN FROG SENSORY NEURON [J].