DETERMINATION OF THE ENANTIOMERS OF MEFLOQUINE IN PLASMA AND WHOLE-BLOOD USING A COUPLED ACHIRAL CHIRAL HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SYSTEM

被引：29

作者：

GIMENEZ, F

FARINOTTI, R

THUILLIER, A

HAZEBROUCQ, G

WAINER, IW

机构：

[1] HOP LA PITIE SALPETRIERE, SERV PHARM & PHARMACO CINET, PARIS, FRANCE

[2] UNIV PHARM PARIX 11, DEPT PHARM CLIN, CHATENAY MALABRY, FRANCE

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1990年 / 529卷 / 02期

关键词：

D O I：

10.1016/S0378-4347(00)83840-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A coupled achiral-chiral high-performance liquid chromatographic system has been developed for the determination of the enantiomers of mefloquine, (+)-MFQ and (-)-MFQ, in plasma and whole blood. The MFQ was separated from the interfering components in the biological matrix and quantified on a cyano-bonded phase, and the enantiomeric composition was determined on an (S)-naphthylurea chiral stationary phase. The two columns were connected by a switching valve equipped with a silica precolumn. The precolumn was used to concentrate the MFQ in the eluent from the achiral column before backflushing onto the chiral phase. The coupled-column system was validated and applied to the analysis of a pilot study of the pharmacokinetics of (+)- and (-)-MFQ in plasma and whole blood. © 1990.

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页码：339 / 346

页数：8

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