CYCLOTHIAZOMYCIN, A NOVEL POLYTHIAZOLE-CONTAINING PEPTIDE WITH RENIN INHIBITORY ACTIVITY - TAXONOMY, FERMENTATION, ISOLATION AND PHYSICOCHEMICAL CHARACTERIZATION

被引：50

作者：

AOKI, M

OHTSUKA, T

YAMADA, M

OHBA, Y

YOSHIZAKI, H

YASUNO, H

SANO, T

WATANABE, J

YOKOSE, K

SETO, H

机构：

[1] NIPPON ROCHE RES CTR,KAMAKURA,KANAGAWA 247,JAPAN

[2] UNIV TOKYO,INST APPL MICROBIOL,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 06期

关键词：

D O I：

10.7164/antibiotics.44.582

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cyclothiazomycin is a novel renin inhibitor produced by Streptomyces sp. NR0516. It was isolated from fermentation broth by extraction with butyl alcohol, QAE-Toyopearl column chromatography and preparative HPLC. Cyclothiazomycin, which was determined to be a unique polythiazole-containing bicyclic peptide, exhibited inhibitory activity against human plasma renin with IC50 being 1.7-mu-M.

引用

收藏

页码：582 / 588

页数：7

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